hrp0092rfc7.3 | Diabetes and Insulin Session 2 | ESPE2019

Osteopontin as an Early Urinary Marker of Diabetic Nephropathy in Adolescents with Type 1 Diabetes Mellitus

Ibrahim Amany , Soliman Hend , Abdullatif Mona , Sabry Aly

Introduction: Patients with type 1 diabetes (T1D) have a higher rate of morbidity and mortality compared with the general population, which varies across countries. Diabetic nephropathy (DN) is a common and serious complication of T1D. Osteopontin (OPN) is a calcium binding phosphoprotein that is expressed in glomerular basement membrane. OPN can be a potential marker of vasculopathy and subclinical atherosclerosis and hence a predictor of DN in T1D patients. ...